Nicotine anxiogenic and rewarding effects are decreased in mice lacking β-endorphin
نویسندگان
چکیده
منابع مشابه
Nicotine-induced antinociception, rewarding effects, and physical dependence are decreased in mice lacking the preproenkephalin gene.
It has been shown previously that the endogenous opioid system may be involved in the behavioral effects of nicotine. In the present study, the participation of endogenous enkephalins on nicotine responses has been investigated by using preproenkephalin knock-out mice. Acute nicotine-induced hypolocomotion remained unaffected in these mice. In contrast, antinociception elicited in the tail-imme...
متن کاملSelective Reward Deficit in Mice Lacking -Endorphin and Enkephalin
It has been impossible to unequivocally identify which endogenous opioids modulate the incentive value of rewarding stimuli because these peptides are not highly selective for any single opioid receptor subtype. Here, we present evidence based on the measurement of instrumental behavior of -endorphin and enkephalin knock-out mice that both opioid peptides play a positive role. A progressive rat...
متن کاملAnxiogenic-like effects of chronic nicotine exposure in zebrafish.
Nicotine is one of the most widely used and abused legal drugs. Although its pharmacological profile has been extensively investigated in humans and rodents, nicotine CNS action remains poorly understood. The importance of finding evolutionarily conserved signaling pathways, and the need to apply high-throughput in vivo screens for CNS drug discovery, necessitate novel efficient experimental mo...
متن کاملAttenuation of Nicotine-Induced Antinociception, Rewarding Effects, and Dependence in -Opioid Receptor Knock-Out Mice
Fernando Berrendero,1 Brigitte L. Kieffer,2 and Rafael Maldonado1 Laboratori de Neurofarmacologia, Facultat de Ciéncies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain, and Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur, BP 1...
متن کاملAttenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice.
The involvement of mu-opioid receptors in different behavioral responses elicited by nicotine was explored by using mu-opioid receptor knock-out mice. The acute antinociceptive responses induced by nicotine in the tail-immersion and hot-plate tests were reduced in the mutant mice, whereas no difference between genotypes was observed in the locomotor responses. The rewarding effects induced by n...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2009
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2009.03.013